Research compound reference
Epithalon
Epithalon is a synthetic linear tetrapeptide: four amino acids joined by peptide bonds. The material is a white to off-white lyophilized powder of 99% or greater purity by HPLC, with a lot-specific Certificate of Analysis, for in vitro laboratory research. This page is a technical reference to the material's identity, chemistry, analytical testing and laboratory handling.
For research use only. Not for human or veterinary, diagnostic or therapeutic use.
The peptide, residue by residue
A single unbranched chain of four amino acids, read from the free amino end (N-terminus) to the free carboxylic acid end (C-terminus).1
H-AEDG-OH
What is Epithalon?
Epithalon is a synthetic linear tetrapeptide: four amino acids joined by peptide bonds. It is catalogued under CAS 307297-39-8 and PubChem CID 219042, with the molecular formula C14H22N4O9 and a molecular weight of 390.35 g/mol.1
The material described on this page is a synthetic peptide intended as a laboratory reagent.
Composition
The four residues are alanine, aspartic acid, glutamic acid and glycine. Counting a free amino end and a free carboxylic acid end, the peptide carries a calculated net charge of about minus two at pH 7.
The sequence contains no cysteine, methionine or tryptophan, the residues most prone to air oxidation in peptides.2
Handling
Epithalon is a dry solid as received in the laboratory. General handling guidance for lyophilized peptides applies.2
How each lot is tested
Each lot is tested by an independent third-party laboratory.3 The Epithalon certificate page names the testing laboratories and lists each lot's purity, net content and test date. Three measurements are reported.
Identity
Mass spectrometry
Checks that the measured molecular mass matches Epithalon. The calculated monoisotopic mass is 390.14 Da.1
A matching mass is consistent with the expected composition. It does not confirm the order of residues.
Purity
High-performance liquid chromatography (HPLC)
Separates the material from synthesis-related impurities. Purity is reported as the main peak's share of the total detected signal.
Reported per lot. The Oasis Labs specification is 99% or greater.
Quantity
Net content
Measures the mass of material actually present in the sample tested.
Reported per lot on the Certificate of Analysis.
Technical notes
What does the Certificate of Analysis confirm?
Identity by mass spectrometry, purity by HPLC, and the net content of the sample. Mass spectrometry confirms molecular mass, not the order of residues.
Why do molecular weights for Epithalon differ slightly between sources?
The figure of 390.35 g/mol is for the form described in the cited PubChem record. Salt forms carry extra counter-ion mass and are often registered separately.
Why is the material freeze-dried?
Peptides are most stable as dry solids. Moisture reduces long-term stability, so the material is lyophilized and kept sealed until use in the laboratory.
Epithalon lot certificates
Each listed Epithalon lot has its own certificate covering identity, purity and net content.
Catalogue entry: Epithalon
More from the research reference
References
- National Center for Biotechnology Information. PubChem Compound Summary for CID 219042 (Epithalon). pubchem.ncbi.nlm.nih.gov/compound/219042. Accessed 20 October 2026.
- MilliporeSigma (Merck KGaA). Handling and storage guidelines for peptides and proteins (technical article). merckmillipore.com. Accessed 14 October 2026.
- Oasis Labs. Epithalon Certificate of Analysis page, lot data and testing laboratories (certificate page), and testing methodology, myoasislabs.com/coa-process/.
References document the chemical identity, analytical characterisation and handling of this material. Molecular composition and the calculated net charge are derived from the published sequence.